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The occluded patch test seemed to indicate that the was quantified by HPLC using an adaptation of a method ... saline ~PBS! at pH 5.5 ~USP,2007! in a glass vial.The system
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115 mg of the compound of formula (I) was added to an 8 ml glass vial, 4 ml of tetrahydrofuran was added, and the solution was sonicated by ultrasonication; then 1.05 equivalent of p-toluenesulfonic acid monohydrate was slowly added. The suspension sample was placed on a magnetic stirrer (40 ° C) and stirred for 16 hours.
I f it is similar to a lagnmurian one it will be that way, but the shape of the peak can be with a fronting if the isotherm is a more complex one. I advise to study Schmidt-Traub, H. (2005).
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China Prior art keywords vlt wahlen patch transdermal therapeutic cohesive Prior art date 2015-02-04 Application number CN201680019543.5A Other languages Chinese (zh)
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